Hi,
yeah, you could try to copy paste the file to a different location. the e drive is generally a cd rom or dvd drive in common pc setup, so this could play a role. try to move it somewhere else.
if you can't do that because of the nature of your environment and how it's going to run on the client's computer, then I am not sure.
Have you tried to run it when published? is it happening only in editor would be the question to answer at this point.
Bye,
Jean