Hi,
It really depends what going on when activating, activating in itself isn't the problem, it's what all the behaviors are going to do when they get activated. so this is where you need to investigate.
-- look at the GameObject you activate, and see what's done at the beginning. Typically, the usual issue is setup, where you try to find objects in the scene by name, and that's known to be impacting perfs.
Bye,
Jean