Hi,
You will need to profile and get a better overview of what is causing this lag, else it will be difficult for you to progress on that front.
-- have you try to run this without any editor window? just the gameview? does it run better. Unity Editor + PlayMaker Editor really takes a lot of resources so your game perf is never really something to account for within Unity Editor so much.
-- what exactly are you doing with these colliders? what do you check, how do you check, and what logic are you running based on colliders/triggers collisions? that's likely what takes up perfs, not just the fact that you have lots of colliders.
bye,
Jean