Hi,
from the profiler, your issue comes from FixedUpdate, which leads me to think you have an issue with your physics setup.
PlayMaker executes actions, which in turns control Unity, If one of these actions does something that affects performances, then you need to solve this, and PlayMaker has nothing to do with it per say. Does that make sense?
If you can't solve this, Send me a package with a scene which repro your issue, and I'll have a look.
Bye,
Jean